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2-oxoisovalerate dehydrogenase (acylating) : ウィキペディア英語版 | 2-oxoisovalerate dehydrogenase (acylating)
In enzymology, a 2-oxoisovalerate dehydrogenase (acylating) () is an enzyme that catalyzes the chemical reaction :3-methyl-2-oxobutanoate + CoA + NAD+ 2-methylpropanoyl-CoA + CO2 + NADH The 3 substrates of this enzyme are 3-methyl-2-oxobutanoate, CoA, and NAD+, whereas its 3 products are 2-methylpropanoyl-CoA, CO2, and NADH. This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-methyl-2-oxobutanoate:NAD+ 2-oxidoreductase (CoA-methyl-propanoylating). Other names in common use include 2-oxoisovalerate dehydrogenase, and alpha-ketoisovalerate dehydrogenase. This enzyme participates in valine, leucine and isoleucine degradation. ==References==
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